Aaron Michael Milstone, M.D., M.H.S.

Headshot of Aaron Michael Milstone
  • Associate Hospital Epidemiologist, Johns Hopkins Hospital
  • Professor of Pediatrics
Male

Expertise

Pediatric Infectious Disease

Research Interests

Prevention of hospital-acquired infections; Epidemiology of multi-drug-resistant bacteria in hospitalized children; Diagnosis and transmission of respiratory viruses in hospitalized children; Methicillin-resistant staphylococcus aureus; Hospital epidemiology; Respiratory infections in children; Epidemiology of multidrug-resistant bacteria in hospitalized children ...read more

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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Locations

Johns Hopkins Pediatrics

Appointment Phone: 410-614-3917
200 N. Wolfe Street
Rubenstein Child Health Building
Baltimore, MD 21287
Phone: 410-614-3917 | Fax: 410-614-1491
Johns Hopkins Pediatrics - Google Maps

Background

Dr. Aaron M. Milstone is a professor of pediatrics at the Johns Hopkins University School of Medicine. He holds a joint appointment in Epidemiology at the Bloomberg School of Public Health.

A pediatric epidemiologist, Dr. Milstone specializes in treating infectious diseases in children. He serves as an associate hospital epidemiologist at The Johns Hopkins Hospital and the pediatric lead for infection prevention for the Johns Hopkins Health System.

Dr. Milstone earned his medical degree from Yale University School of Medicine. He completed both a pediatrics residency and a research fellowship in pediatric infectious diseases at Children's Hospital of Philadelphia. He also completed a pediatric infectious diseases fellowship at Johns Hopkins. He holds a M.H.S. (Graduate Training Program in Clinical Investigation) from the Johns Hopkins Bloomberg School of Public Health and Johns Hopkins University School of Medicine. Dr. Milstone joined the Johns Hopkins faculty in 2007.

His research interests focus on antibiotic resistance and prevention of healthcare-associated infections. He had led numerous clinical trials including the Pediatric SCRUB Trial and TREAT PARENTS Trial testing strategies to prevent organism transmission and healthcare-associated infections. He is principal investigator of the BrighT STAR Collaborative, guiding hospitals nationwide to reduce over-testing as a strategy to reduce antibiotic use and resistance.

Dr. Milstone is a fellow of the American Academy of Pediatrics, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society for Healthcare Epidemiology of America. His many other professional honors include the Pediatric Infectious Diseases Society’s 2014 Young Investigator Award, the inaugural 2013 Caroline B. Hall Clinical Innovation Award, and the Society for Healthcare Epidemiology of America 2018 Mentor Scholar Award.

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Titles

  • Associate Hospital Epidemiologist, Johns Hopkins Hospital
  • Professor of Pediatrics

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Yale School of Medicine (2000)

Residencies

  • Pediatrics; The Children's Hospital of Philadelphia (2003)

Fellowships

  • Pediatric Infectious Diseases; Johns Hopkins University School of Medicine (2007)

Board Certifications

  • American Board of Pediatrics (Pediatric Infectious Diseases) (2007)
  • American Board of Pediatrics (Pediatrics) (2003)

Research & Publications

Research Summary

Dr. Milstone’s research focuses on the prevention of hospital-acquired infections (HAIs) and the emergence of antibiotic resistance in children.

His work is helping to define the prevalence and transmission of multi-drug-resistant bacteria in hospitalized children and to identify interventions to reduce their spread and prevent HAIs.

Dr. Milstone is investigating topics that include:

  • Interventions to reduce the spread of multi-drug-resistant bacteria and prevent HAIs in hospitalized children
  • Safety and efficacy of decolonization in preventing HAIs in children
  • Epidemiology and prevention of central line-associated bloodstream infections

Some of Dr. Milstone’s recent work has focused on understanding the mechanisms of bacterial drug-resistance and on developing strategies to prevent hospital-acquired infections among critically ill children. His research findings have fueled innovative risk-reduction protocols—including the use of daily antiseptic baths to reduce the risk of bloodstream infections in critically ill children—and led to their widespread practice in pediatric hospitals across the U.S.

Clinical Trials

Selected Publications

View all on PubMed

Milstone AM, Elward A, Song X, Zerr DM, Orscheln R, Speck K, Obeng D, Reich NG, Coffin SE, Perl TM. Daily Chlorhexidine Bathing to Reduce Bacteraemia in Critically Ill Children: a Multicentre, Cluster-Randomised, Crossover Trial. Lancet. 2013 Mar 30;381(9872):1099-106. Epub 2013 Jan 28.(selected by Faculty of 1000)

Milstone AM, Voskertchian A, Koontz DW, Khamash DF, Ross T, Aucott SW, Gilmore MM, Cosgrove SE, Carroll KC, Colantuoni E. Effect of Treating Parents Colonized With Staphylococcus aureus on Transmission to Neonates in the Intensive Care Unit: A Randomized Clinical Trial. JAMA. 2020 Jan 28;323(4):319-328. doi: 10.1001/jama.2019.20785

Colantuoni E, Milstone AM. Low Diversity in Nasal Microbiome Associated With Staphylococcus aureus Colonization and Bloodstream Infections in Hospitalized Neonates. Open Forum Infect Dis. 2021 Sep 18;8(10)

Zhong D, Xiao S, Debes AK, Egbert ER, Caturegli P, Colantuoni E, Milstone AM. Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection. JAMA. 2021 Nov 1

Woods-Hill CZ, Colantuoni EA, Koontz DW, Voskertchian A, Xie A, Thurm C, Miller MR, Fackler JC, Milstone AM; and the Bright Star Authorship group. Diagnostic stewardship for blood cultures in critically ill children: results of the Bright STAR Collaborative. JAMA Pediatr. 2022 May 2

Activities & Honors

Honors

  • Election to Alpha Omega Alpha, 2000
  • Pediatric Infectious Diseases Society Award recognizing outstanding poster presentation at IDSA National Meeting, 2005
  • Fellow, American Academy of Pediatrics, 2005
  • Fellowship Award, National Pediatric Infectious Disease Society, 2005 - 2007
  • Pediatric Infectious Diseases Society Award recognizing outstanding poster presentation at IDSA National Meeting, 2007
  • Clinical Research Scholars Award, Johns Hopkins Medicine, 2007 - 2009
  • Pediatric Investigator Award, Society for Healthcare Epidemiology of America, 2010
  • Excellence in Teaching Award, Johns Hopkins Bloomberg School of Public Health, 2011
  • Inaugural Caroline B. Hall Clinical Innovation Award, Pediatric Infectious Diseases Society, 2013
  • Election to Society for Pediatric Research, 2013
  • Fellow, Society for Healthcare Epidemiology of America, 2013
  • Young Investigator Award, Pediatric Infectious Diseases Society, 2014
  • Fellow, Infectious Diseases Society of America, 2014
  • Top Doctors, Infectious Diseases, Baltimore Magazine, 2012 - 2014
  • Fellow, Pediatric Infectious Diseases Society, 2017
  • Mentor Scholar Award, Society for Healthcare Epidemiology of America, 2018
  • Top Doctors, Infectious Diseases, Baltimore Magazine, 2016 - 2019
  • Award for Excellence in Mentoring, Johns Hopkins University School of Medicine, 2020

Memberships

  • American Academy of Pediatrics
  • Infectious Diseases Society of America
  • Pediatric Infectious Diseases Society
  • Society for Healthcare Epidemiology of America

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